|
週次 |
日期 |
單元主題 |
|
第1週 |
2/26 |
1. 文惠
Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells
Cancer Res. 2017 Mar 15;77(6):1453-1464
2. 潔雯
VEGFR2-Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy.
Cancer Res. 2018 Feb 1;78(3):731-741.
|
|
第2週 |
3/05 |
1. 宇暄
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.
2. 方妤
Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells: - Preclinical Validation in Human CD34+ Stem and Progenitor Cells. |
|
第3週 |
3/12 |
1. 亦欣
Podocalyxin-Like Protein 1 Regulates TAZ Signaling and Stemness Properties in Colon Cancer. Int. J. Mol. Sci. 2017, 18(10), 2047-2058.
2. 怡臻
Deregulation of kinase signaling and lymphoid development in EBF1-PDGFRB ALL leukemogenesis
Leukemia (2018) 32, 38–48; doi:10.1038/leu.2017.166
|
|
第4週 |
3/19 |
1. 映辰Progress report :
Cytotoxic effects imposed by the Botanical Alkyl Hydroquinone Derivative HQ17(3) on the Philadelphia Chromosome Positive ALL SUP-B15 Cells.
2. 克巍Progress report:
Investigating tumor suppressive effects of
microRNAs in human neuroblastoma using
CRISPR/CAS9-mediated gene targeting in
SH-SY5Y cells.
|
|
第5週 |
3/26 |
1. 黃焱Progress report :
TALDO1-DSN1 fusion gene regulates the progression of hematopoietic disorders in transgenic zebrafish.
2. Cancer killers in the human gut microbiota: diverse phylogeny and broad spectra
. Oncotarget (2017) Vol. 8(30), pp: 9574-49591
|
|
第6週 |
4/02 |
溫書假 |
|
第7週 |
4/09 |
Progress report :
Investigating the anti-cancer mechanisms of pyrvinium pamoate on cabozantinib-resistant Molm13-XR leukemic cells (文惠)
Progress report :
Inhibition of metabolic pathway as a therapeutic strategy in acute myeloid leukemia harbouring FLT3-ITD mutation(潔雯)
|
|
第8週 |
4/16 |
Targeting acute myeloid leukemia by drug-induced c-MYB degradation. (宇暄)
Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis
(芳妤) |
|
第9週 |
4/23 |
CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo
(克巍)
Shift in energy metabolism caused by glucocorticoids enhances the effect of cytotoxic anti-cancer drugs against acute lymphoblastic leukemia cells
(映辰)
|
|
第10週 |
4/30 |
Characterization of oral and gut microbiome temporal variability in hospitalized cancer patients (育安)
The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells (黃焱)
|
|
第11週 |
5/07 |
Measurement of serum PODXL concentration
for detection of pancreatic cancer. (亦欣)
Epigenetic silencing of miR-125b is required for normal B-cell development. (怡臻)
|
|
第12週 |
5/14 |
Mitochondrial dysfunction induced by a SH2
domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells. (文惠)
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. (潔雯)
|
|
第13週 |
5/21 |
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation(方妤)
Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy.(宇暄) |